Zoledronic acid monohydrate

CAS No. 165800-06-6

Zoledronic acid monohydrate( Zoledronic acid hydrate | CGP 42446 | CGP42446A | ZOL 446 | zoledronate | zoledronate )

Catalog No. M27387 CAS No. 165800-06-6

Zoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
25MG 48 In Stock
50MG 69 In Stock
100MG 114 In Stock
200MG 169 In Stock
500MG 264 In Stock
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Biological Information

  • Product Name
    Zoledronic acid monohydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Zoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
  • Description
    Zoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
  • In Vitro
    Zoledronic Acid monohydrate (0.1-1 μM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) induces apoptosis in MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 4 days) inhibits cell viability due to the induction of apoptosis.Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 μM. Cell Viability Assay Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:1 day, 3 days, 5 days, 7 days Result:Reduced cells viability at 10 μM and 100 μM.Apoptosis Analysis Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:1 days, 4 days, 7 days Result:Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations).Western Blot Analysis Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:4 days Result:Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 μM.
  • In Vivo
    Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties. Animal Model:Five-week-old C57BL6 mice Dosage:0.05 mg/kg, 0.5 mg/kg, 1 mg/kg Administration:Intraperitoneal injection, weekly, for 3 weeks Result:Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg.
  • Synonyms
    Zoledronic acid hydrate | CGP 42446 | CGP42446A | ZOL 446 | zoledronate | zoledronate
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    165800-06-6
  • Formula Weight
    290.105
  • Molecular Formula
    C5H12N2O8P2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 14.29 mg/mL (49.26 mM)
  • SMILES
    O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Habtamu A, Melaku Y. Antibacterial and Antioxidant Compounds from the Flower Extracts of Vernonia amygdalina. Adv Pharmacol Sci. 2018 Mar 20;2018:4083736. doi: 10.1155/2018/4083736. PMID: 29755517; PMCID: PMC5884303.
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