
Zoledronic acid monohydrate
CAS No. 165800-06-6
Zoledronic acid monohydrate( Zoledronic acid hydrate | CGP 42446 | CGP42446A | ZOL 446 | zoledronate | zoledronate )
Catalog No. M27387 CAS No. 165800-06-6
Zoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
Purity : >98% (HPLC)






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50MG | 69 | In Stock |
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100MG | 114 | In Stock |
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200MG | 169 | In Stock |
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500MG | 264 | In Stock |
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Biological Information
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Product NameZoledronic acid monohydrate
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NoteResearch use only, not for human use.
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Brief DescriptionZoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
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DescriptionZoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
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In VitroZoledronic Acid monohydrate (0.1-1 μM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) induces apoptosis in MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 4 days) inhibits cell viability due to the induction of apoptosis.Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 μM. Cell Viability Assay Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:1 day, 3 days, 5 days, 7 days Result:Reduced cells viability at 10 μM and 100 μM.Apoptosis Analysis Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:1 days, 4 days, 7 days Result:Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dose-dependent and time-dependent (high concentrations).Western Blot Analysis Cell Line:MC3T3-E1 cells Concentration:0.02 μM , 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:4 days Result:Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100 μM.
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In VivoZoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties. Animal Model:Five-week-old C57BL6 mice Dosage:0.05 mg/kg, 0.5 mg/kg, 1 mg/kg Administration:Intraperitoneal injection, weekly, for 3 weeks Result:Inhibited both osteoclast and osteoblasts function and bone remodeling at 0.5 mg/kg and 1 mg/kg.
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SynonymsZoledronic acid hydrate | CGP 42446 | CGP42446A | ZOL 446 | zoledronate | zoledronate
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PathwayApoptosis
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TargetApoptosis
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number165800-06-6
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Formula Weight290.105
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Molecular FormulaC5H12N2O8P2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 14.29 mg/mL (49.26 mM)
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SMILESO.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Habtamu A, Melaku Y. Antibacterial and Antioxidant Compounds from the Flower Extracts of Vernonia amygdalina. Adv Pharmacol Sci. 2018 Mar 20;2018:4083736. doi: 10.1155/2018/4083736. PMID: 29755517; PMCID: PMC5884303.
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